HIV/AIDS is changing the landscape of family and home for South African children and youth. Across rural parts of the country, children’s need for protection from HIV exposure and violence is increasing as they lose caregivers to the virus. When this happens, the social, psychological, and material support that caregivers provide is also lost. Now, more than ever, communities must take responsibility for the care and support of these vulnerable young people. In response, grassroots groups are focusing on ways to prioritise child safety and protection in the areas most affected.